The Vermont Blueprint for Health designs community-led strategies for improving health and well-being. The Blueprint’s design work responds to the emerging needs of Vermonters and the latest opportunities in health and human services reform by creating change in the delivery system. This work began with Patient-Centered Medical Homes, Community Health Teams, and Self-Management and Healthier Living Workshops. It subsequently expanded to include the Hub & Spoke system of opioid use disorder treatment, and the Women’s Health Initiative. In support of program implementation, full population data and analytics and learning collaboratives are available for policy makers, communities, and practices.